Wira Eka Putra, Firda Agustin, Lailiyavina Rochmatika, Wa Ode Salma
Cancer is the biggest causes of death in the world and lung cancer take the greatest prevalence compared with all cancer incidences. The most dominant type of lung cancer is non-small cell lung cancer (NSCLC) which is generally caused by changes in the genetic composition of epidermal growth factor receptor (EGFR)-tyrosine kinase. Furthermore, the genetic changes of EGFR-tyrosine kinase contribute in developing resistance to anti-cancer drugs. Indonesian medicinal plants exert massive therapeutic advantages; one of them is anti-cancer potency. This research aimed to evaluate anti-cancer potency of Indonesian medicinal plants as lung-cancer therapeutic strategy through in silico. In this study, the practical methods were divided into three major parts including materials retrieval, molecular docking process by using AutoDock Tools, and visualization and docking analysis by using Discovery Studio 4.0. According to the molecular docking result, there were three bioactive compounds of Indonesian medicinal plants which have lower Gibbs free energy than gefitinib as control. Those three bioactive compounds consist of berberin (∆G= -8.1 kcal/mol), physcionin (∆G= -7.9 kcal/mol), and pinostrobin (∆G= -7.4 kcal/mol) which predicted to have anti-cancer properties greater than gefitinib (∆G= -5.9 kcal/mol). © 2019 Malaysian Society for Biochemistry and Molecular Biology. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia; Program Studi Gizi Klinik, Jurusan Kesehatan, Politeknik Negeri Jember, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia; Department of Nutrition, Faculty of Medicine, Halu Oleo University, Indonesia
