Bayyinatul Muchtaromah, Siti Imroatul Maslikah, Lailil Mufarrichah, Prilya Dewi Fitriasari
Earthworms (Lumbricus rubellus) can be used as medicine for typhus caused by Salmonella typhi. The active compounds in earthworms include lysozyme, agglutinin, lytic factor, and lumbricine. The treatment of flour worms with concentration and duration of administration improperly influence the S. typhi inhibition in vivo. This study aimed to determine the effect of concentration and duration of worm flour administration on the histological description of the small intestine and kidney of white rats (R. norvegicus) infected with the S. typhi. The first factor was the concentration of worm flour (32%, 48% and 60%), and the second factor was the duration of administration (7 days and 14 days). Data were analyzed by two-way ANOVA. The results showed that the concentration and duration of worm flour administration affected improving the histological damage of the small intestine and kidneys of rats, but the interaction of concentration and duration of worm flour administration did not show a significant effect. The effective treatment was found at a concentration of 60%, with a duration of 14 days. © 2019 Author(s).
Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik, Ibrahim Malang, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, State University of Malang, Indonesia
