Indra Ariyadi, Hendra Susanto, Ahmad Taufiq, Sugiharto, Desiana Merawati, Khumaira Marsyidah Badu, Jerry Dwi Trijoyo Purnomo, Melati Putri Pertiwi, Elhah Nailul Khasna, I. Kade Karisma Gita Ardana
Metabolic syndrome and physical activity entail a significant correlation to the gradual augmentation of degenerative disease incidence in the global population. Currently, several approaches have been applied to prevent the progression of metabolic syndrome, including clinical drug therapy and physical training program. However, little attention has been addressed to investigate whether acute medium intensity exercise (AMIE) co-treated with middle rhythm musical exposure can affect to thermogenesis and fatty acid oxidation. To fill this void, this present study was designed by applying AMIE and music on 45 individuals, non-professional athletes to evaluate the potential inducer of thermogenic activity (PGC-1α) profile in the muscle and adipose tissue. The finding of this study showed that AMIE exposure was significantly induced by the increase of circulating PGC-1α as linear to the high-intensity exercise group. On the contrary, the expression of this transcription factor led to decreased post-AMIE-musical co-treatment. It is suggested that AMIE can induce thermogenesis in the skeletal muscle and adipose tissue by modulating oxidative phosphorylation within mitochondria. In summary, the AMIE model may provide an alternative solution to combat metabolic syndrome linked obesity through enhancing the beta-oxidation process. Thus, the expanding investigation with a large sample and long-term monitoring program is required to establish this physical training program in the population. © 2020 American Institute of Physics Inc.. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia; Department of Sports Science, Faculty of Sports Science, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia; Department of Statistics, Faculty of Mathematics, Computation, and Data Science, Institut Teknologi Sepuluh November, Surabaya, Indonesia
