Hendra Susanto, Nan-Shan Liou, Bogi Pratomo, Tinny Endang Hernowati, Adeodatus Yuda Handaya, Hani Susianti, Moch Bachtiar Budianto, Abdul Gofur, Eviana Norahmawati, Nia Lukita Ariani
The epidemiologic evidence has been proved that chronic hepatitis C (CHC) infection may significantly contribute to the progression of hepatocellular carcinoma (HCC). Moreover, the prevalence of individuals with CHC infection in Indonesia increased dramatically during the last decade. Importantly, there is no preliminary data, whether specific liver derived-hormone, betatrophin/ANGPTL-8/ can contribute to the early stage of HCC caused by HCV infection. The goal of this study was to provide baseline data of betatrophin profile in subjects with CHC. Nineteen healthy control and fourteen CHC patients were considered as the samples, and circulating betatrophin was measured by ELISA. Interestingly, the higher level of betatrophin was observed in an individual with CHC compared to placebo. Furthermore, the linear data was also found that the classical marker of liver injury, ALT significantly increased in the same patients. Based on this critical data, it is suggested that betatrophin may contribute to the early stages of HCC in connection to the gradual changes of HCV DNA and ALT level. Even though this finding could be a hallmark for the essential characteristic of betatrophin in CHC subjects progress to HCC, however, the future study with long-term monitoring in clinical observation of CHC patients is compulsory. © 2020 American Institute of Physics Inc.. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia; Department of Internal Medicine, National Taiwan University Hospital-, Hsinchu Branch, Hsinchu, Taiwan; Department of Endocrinology, Saiful Anwar General Hospital, Malang, Indonesia; Department of Clinical Pathology, Saiful Anwar General Hospital, Malang, Indonesia; Division of Surgical Oncology, Department of Surgery, Saiful Anwar General Hospital, Malang, Indonesia; Department of Surgery, Sardjito General Hospital, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pathology Anatomy, Saiful Anwar General Hospital, Malang, Indonesia; Department of Nursing Science, Universitas Tribhuwana Tunggadewi, Malang, Indonesia
