Wira Eka Putra, Wa Ode Salma, Diana Widiastuti, Muhammad Kismurtono
Diabetes mellitus still become a serious health problem globally. The prevalence of this incidence has become increasing over the years. Current treatment has been applied, however, the new strategy is still needed to explore. Thus, in order to combat diabetes mellitus, we aimed to evaluate the potential activity of compounds from Eugenia jambolana stem bark as PPARG-agonist agents. In silico screening was performed to assess the possible and potential compounds as anti-diabetic agents. Based on our findings, we noted there are three potential compounds as PPARG-agonist, namely ellagic acid, myricetin, and friedelin. These compounds were selected based on the binding affinity scores and interaction patterns against the target protein. In detail, the ligand-protein interaction of these three compounds are ellagic acid - PPARG interaction (Van der Waals, Conventional Hydrogen Bond, Pi-Anion, and Pi-Alkyl); myricetin - PPARG interaction (Van der Waals, Conventional Hydrogen Bond, Pi-Sulfur, and Pi-Alkyl); and friedelin - PPARG interaction (Van der Waals and Alkyl/ Pi-Alkyl). From this finding, extensive research is needed to evaluate the biological function of these ligands as an anti-diabetic agent. © 2020 Malaysian Society for Biochemistry and Molecular Biology. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia; Department of Biotechnology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia; Department of Nutrition, Faculty of Public Health, Halu Oleo University, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Pakuan, Indonesia; Research Unit for Natural Product Technology, Indonesian Institute of Science, Indonesia
