Nanda Earlia, Mikyal Bulqiah, Muslem Muslem, Taufiq Karma, Rivansyah Suhendra, Aga Maulana, Mohamad Amin, Novi Reandy Sasmita, Ghazi Mauer Idroes, Crs Prakoeswa, Eko Suhartono, Khairan Khairan, Rinaldi Idroes
A protective effect of Acehnese traditionally fermented coconut oil (Pliek U oil) and its residue (Pliek U) have been studied against UVB radiation. The research was performed by preparing the active ingredient in ointment formulation and protective test in male Wistar rat skin (Rattus novergicus). Four different extraction methods were done to produce four active ingredients, that are Pliek U oil (PUO), ethanolic Pliek U oil extract (EPUOE), ethanolic Pliek U extract (EPUE), and ethanolic hexane residue Pliek U extract (EHRPUE). The protective effect was determined based on the erythema index (EI), melanin index (MI), and level of protein oxidation parameters. The protective level from each active ingredient was studied by PCA analysis. The result showed that the active ingredient could inhibit the redness and protein oxidation in skin tissue. PCA results show that concentration (20 v. 40%) does not affect the protection level of the active ingredients of Pliek U oil, but it does affect the one of Pliek U. Therefore, these active ingredients are potential for sunscreen application. © 2021 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.
Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; General Hospital Zainoel Abidin, Banda Aceh, 24415, Indonesia; Department of Chemistry, Universitas Islam Negeri Ar-Raniry, Banda Aceh, 23111, Indonesia; Department of Chemistry, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Departement of Informatics, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, 65145, Indonesia; Computational and Applied Statistics Research Group, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Department of Chemical Engineering, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Faculty of Medicine, Universtas Airlangga-Dr Soetomo, General Academic Hospital, Surabaya, 60132, Indonesia; Department of Medical Chemistry/Biochemistry, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, 70712, Indonesia; Departement of Pharmacy, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia; Pusat Riset Obat Herbal, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia
