Hendra Susanto, Fahdina Rufiandita, Gufron Alifi, Ahmad Taufiq, Wira Eka Putra, Ainul Mardiah, Dianvita Nur Fadhilah, Naily Salma Abadi, Novi Sanita Putri, Siti Bachrotus Recha Nur Fa'ida
Chronic inflammation is the initial stage of liver fibrosis-related hepatocellular carcinoma (HCC) development. Also, HCC is a global disease resulting from several etiological factors. HCC incidence can be triggered by alcohol abuse, non-alcoholic steatohepatitis (NASH), viral hepatitis B (HBV), viral hepatitis C (HCV), and non-alcoholic fatty liver disease (NAFLD). Liver chronic inflammation significantly correlates to TNF-α (Tumor Necrosis Factor-α) and IL-6 (interleukin 6) expression. This laboratory work aimed to investigate the effect of green material Moringa oleifera leaf powder (MOLP) on the expression of both pro-inflammatory cytokines. A semi-quantitative approach quantified the expression of TNF-α and IL-6. This research was conducted using an animal model induced by intraperitoneal injection of CCl4 solution. The results showed that green material Moringa oleifera could reduce IL-6 and TNF-α expression. Importantly, MOLP exposure can decrease the pro-inflammatory cell population in the liver parenchymal area. Hence, the application of green material Moringa oleifera might be potential as the local bioresources agent against liver inflammation-linked fibrosis. The exploration of MOLP in the future drug discovery model may significantly contribute to the prevention of hepatocellular carcinoma. © 2021 Author(s).
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia; Department of Biotechnology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia
