Slamet Raharjo, Adi Pranoto, Purwo Sri Rejeki, A.S.M. Harisman, Yualita Putri Pamungkas, Olivia Andiana
BACKGROUND: Obesity has been widely associated with structural and functional changes in brain, whereas inflammation is one of the potential mechanisms involved in these changes. AIM: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index [BMI] and waist to hip ratio [WHR]) and inflammation (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) levels of in females with obesity. METHODS: This study used a cross-sectional study method using 33 female with obesity aged 19–23 years, BMI >27.5 kg/m2, normal blood pressure, normal resting heart rate, normal hemoglobin, and fasting blood glucose ≤100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay method. The data were analyzed using Pearson product-moment test with a significant levels p < 0.05. RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p < 0.001), WHR (r = –0.675; p < 0.001), IL-6 levels (r = –0.530; p < 0.001), and TNF-α levels (r = –0.561; p < 0.001). CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, WHR, and inflammation (IL-6 and TNF-α) levels in females with obesity. Further studies are needed to confirm the present findings. © 2021 Slamet Raharjo, Adi Pranoto, Purwo Sri Rejeki, A. S. M. Harisman, Yualita Putri Pamungkas, Olivia Andiana.
Department of Sports Science, Faculty of Sports Science, State University of Malang, Malang, Indonesia; Department of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Public Health, Faculty of Sports Science, State University of Malang, Malang, Indonesia
