Fathul Zannah, Mohamad Amin, Hadi Suwono, Betty Lukiati
Diplazium esculentum is one of the medicinal plants used by Dayak tribes in Central Kalimantan to cure acne. The potential of D. esculentum can be proved through information on the active compounds of the extract obtained in decoction and infusa methods. Thus, a liquid chromatography-mass spectrophotometry (LC-MS)-based method is developed to identify the active compounds of D. esculentum extract in either decoction method or infusa method. The chemical compound potential of D. esculentum extract was then analysed using bioinformatics approach based upon the database of PASS online server. Results showed that the D. esculentum extract contained 81 chemical compounds in decoction method and 68 compounds in infusa method, in which the dominant compound was flavonoid. Moreover, PASS online web server analysis found 7 flavonoid compound groups potential as anti-acne containing antisebor, AR expression inhibitor and CYP1A1 inhibitor. This information could be very useful for designing a clinical test on plant natural compound potential for traditional drug development © 2022. International Journal Bioautomation.All Rights Reserved
University of Muhammadiyah Palangkaraya Palangkaraya, Central Kalimantan, 63111, Indonesia; Department of Biology Education State University of Malang, East Java, Malang, 65145, Indonesia
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