Abdul Hakim Md Yusop, Murni Nazira Sarian, Fatihhi Szali Januddi, Hadi Nur
Drug-device systems based on biodegradable metals have been of great interest in the last decade due to their local-release regime and the ability of the biodegradable metals to degrade in the physiological environment facilitating tissue growth and gradual load transfer. The biodegradability of the biodegradable metals provides a promising medium that might enable other materials – such as drugs, bioactive materials and therapeutic agents - to be incorporated into the degradable metals to act as a drug-device system that would locally release the drugs or therapeutic agents onto the healing tissue. In comparison to systemic drug delivery, the locally released drug-device system makes the dose control over a specific targeted tissue more efficient and reduces the side effects on non-targeted tissues. This review outlines the current state of development of the biodegradable metals-based drug-device system and focuses in-depth on the potential interactions between the drugs, degradable metallic surfaces, drug carriers, ions and proteins inside the body fluids, which can be a challenge to producing a highly efficient drug-device system. © 2022 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
Materials Research & Consultancy Group (MRCG), Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia; Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Johor, Skudai, Malaysia; Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Johor Bharu, Malaysia; Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Selangor, Bandar Baru Bangi, Malaysia; Advanced Facilities Engineering Technology Research Cluster (AFET), Plant Engineering Technology (PETech) Section, Universiti Kuala Lumpur Malaysian Institute of Industrial Technology, Masai, Johor, Malaysia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia; Center of Advanced Materials for Renewable Energy (CAMRY), Universitas Negeri Malang, Malang, Indonesia