Hendra Susanto, Sugiharto, Ahmad Taufiq, Adi Pranoto, Jerry Dwi Trijoyo Purnomo
Obesity is a global metabolic disease anchored by a lack of physical activity lipid disturbances. Hitherto, betatrophin is a potential liver-derived hormone that regulates lipid metabolism. A total of 26 selected onset obese individuals (BMI range ± 28–31) were enrolled in this study and given moderate-intensity exercise. Importantly, our data show that acute moderate-intensity interval exercise (MIIE) and acute moderate-intensity continue to exercise (MICE) for 40 min significantly decrease the plasma level of full-length betatrophin respectively (174.18 ± 48.19 ng/mL; 182.31 ± 52.69 ng/mL), compared to the placebo (283.97 ± 32.23 ng/mL) post 10 min and 6 h exercise treatment (p ≤ 0.05). The plasma level of betatrophin was significantly and negatively correlated with BMI (r = − 0.412, p = 0.037), fasting blood glucose (r = − 0.390, p = 0.049), and positively correlated with VO2max (r = 0.456, p = 0.019). In addition, the linear and ordinal logistic regression analysis shows that betatrophin, is a potential predictor for BMI [estimate value = 0.995, p = 0.037 and OR (95 % CI) = 0.992 (0.0984–1.00), p = 0,048]. In summary, our data demonstrate that the circulating levels of betatrophin were decreased after acute moderate-intensity exercise training. © 2022 The Author(s)
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Malang, 65145, Indonesia; Department of Sports Science, Faculty of Sports Science, Universitas Negeri Malang, East Java, Malang, 65145, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Malang, 65145, Indonesia; Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60132, Indonesia; Department of Statistics, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, East Java, Surabaya, 60117, Indonesia