Mohamad Amin, Nanda Hilda Khikmawati, Suryadi Suryadi, Rifcha Fachrunnisa, Ihya Fakhrurizal Amin, Dina Maulina, Ahya Zhilalikbar Amin, Nik Ahmad Nizam Nik Malek, Restu Fitriani
There are many uses of natural ingredients to find out their potential in overcoming Coronavirus Disease 2019. One of the plants that is often used to treat various diseases, including SARS-Cov2 infection is turmeric. Turmeric contains Tetrahydroxycurcumin compounds. The aim of this research was to study the potential of Tetrahydroxycurcumin in preventing infection with the SARS-CoV-2 virus. The results showed that Tetrahydroxicurcumin has the potential to inhibit Tyrosine protein kinase ABL1, which is a protein that plays a role in the preparation of the cytoskeleton during viral infection. The binding affinity of Tetrahydroxycurcumin for this protein is -8.4 kcal/mol. © 2023 American Institute of Physics Inc.. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No.5, Malang, 65145, Indonesia; Special Education Department, Faculty of Education, Universitas Negeri Malang, Jl. Semarang No.5, Malang, 65145, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biology Education Study Program, Faculty of Teacher Training and Education, Universitas Lampung, Lampung, Indonesia; Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia; Study Program of Informatics Engineering, Faculty of Computer Sciencies, Universitas Brawijaya, Malang, Indonesia; Biotechnology Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No.5, Malang, 65145, Indonesia
