Mohamad Amin, Choirus Zakinah, Betty Lukiati, Nik Ahmad Nizam Nik Malek
Typhoid fever is a disease caused by infection with the pathogenic bacteria Salmonella typhi. Typhoid fever treatment usually uses antibiotics, but currently many typhoid fever antibiotics are reported to have experienced Multi-Drug Resistant (MDR). Resistance of S. typi to synthetic antibiotics has the risk of causing side effects, so it is necessary to develop antibiotics made from nature, one of which is cloves because they contain active antimicrobial compounds. The results showed that the compounds of -tri-O-methylellagic acid, ellagic acid, eugenetin, eugenin, eugenol, isoeugenitol, kaempferide, kaempferol, rhamnetin, rhamnocitrin and syringic acid were predicted to be potential candidates for anti-typhoid drugs. Ellagic acid is predicted to be the most potential candidate for anti-typhoid drugs with a binding affinity value of -9.9 kcal/mol. The results of this study can be used as a reference for research in the health sector related to the development of anti-typhoid drugs. © 2023 American Institute of Physics Inc.. All rights reserved.
Department of Biology, Faculty of Mathematic and Sciences, Universitas Negeri Malang, Jl. Semarang No.5, Malang, 65145, Indonesia; Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia