Hartatiek Hartatiek, Yudyanto Yudyanto, L.F. Rahim, S. Amalia, M. Nurhuda, Masruroh Masruroh, Dionysius J.D.H. Santjojo
This study aims to fabricate PVA/PEG/Chitosan nanofiber scaffolds for skin tissue engineering. The scaffolds in the nanofiber structure closely match with the ECM structure of the skin tissue. PVA/PEG/Chitosan nanofibers were prepared by electrospinning technique with various compositions (v/v) % (95:5, 90:10, 85:15, 80:20). The scaffold surface morphology was characterized by scanning electron microscopy (SEM), and the functional groups were characterized by Fourier transform infrared (FTIR). The biodegradation test was carried out by immersing the sample in a simulated body fluid (SBF) solution with time variations of 1,2,3, and 4 weeks. The scaffolds have diameters in the range of 110-520 nm, which correspond to the skin ECM, and porosity in the range of 63-71%, which facilitates cell adhesion, and proliferation. The rate of biodegradation is faster in the composition (95:5). The surface morphology with random fiber diameter, porosity, and biodegradation are suitable for skin tissue scaffolding. © 2023 American Institute of Physics Inc.. All rights reserved.
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Jl. Veteran, Malang, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, Indonesia