Sri Rahayu Lestari, Nenes Prastita, Siti Imroatul Maslikah, Sunaryono, Abdul Gofur, Fauziatul Fajaroh, Yuslinda Annisa, Nik Ahmad Nizam Nik Malek
Single garlic has been known have various benefits because it contains many active compounds. The active compounds in garlic, like antioxidants are quickly degraded in the digestive tract. Various attempts have been made to maintain the antioxidants content in garlic through drug delivery systems. One of the drug delivery systems that can protect antioxidants is the Self Nanoemulsifying Drug Delivery System (SNEDDS). This study aims to characterize and test the antioxidant activity of SNEDDS single garlic extract (SGE). The methods used include single garlic extraction with ethanol solvent, SNEDDS formulation, SNEDDS preparation, SNEDDS response test, and physical tests. Characterization of SNEDDS size and morphology using Particle Size Analyzer (PSA) and Transmission Electron Microscopy (TEM). An antioxidant activity test was carried out using the DPPEI method. The results showed that the mean droplet size of SNEDDS-SGE was 23.10 ± 0.69 nm, the polydispersity index (PDI) was 0,46 ± 0,01 and the Zeta potential was -33.07±0.45 mV. The morphology of SNEDDS is a round droplet. The results of the antioxidant activity test showed that the percentage of antioxidant activity of SNEDDS-SGE was 56.74±1,04 which was higher than the percentage of antioxidant activity of SGE that was not prepared with SNEDDS 17.56 ±0.08. © 2023 American Institute of Physics Inc.. All rights reserved.
Department of Biology, Faculty Mathematics and Natural Science, Universitas Negeri Malang, East Java, Malang, Indonesia; Department of Physics, Faculty Mathematics and Natural Science, Universitas Negeri Malang, East Java, Malang, Indonesia; Department of Chemistry, Faculty Mathematics and Natural Science, Universitas Negeri Malang, East Java, Malang, Indonesia; Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, 81310, Malaysia; Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Johor Bahru, 81310, Malaysia