Aliyya Suci Arizona, Wira Eka Putra, Hendra Susanto, Sustiprijatno, Arief Hidayatullah, Muhammad Fikri Heikal, Diana Widiastuti
The hepatitis C virus (HCV) is the causative agent of hepatitis C, an infection of the liver. The liver may suffer long-term damage as a result of this illness. A significant number of people in Indonesia are infected with hepatitis C. Because of the restrictions and potential side effects of their hepatitis C treatment, a large number of people decide to stop receiving medication. Traditional remedies made from plants have started to become more popular in recent years due to the fact that they are less expensive and have less adverse effects. Thus, in this present study we aimed to evaluate the Vigna radiata active constituent as possible anti-viral drug against Hepatitis C Virus Envelope E2 Glycoprotein through in silico approaches. The Lipinski rule of five is used in the process of virtually screening compounds to identify those that have properties similar to candidate of drug. Following that, the target chemicals and proteins were adjusted in preparation for additional molecular docking. In order to get binding affinity scores, chemical interactions, ligands sites, and amino acid residues, visualization and data analysis were carried out. Based on our investigation, we found top five molecules with lower binding energy values than IFN-α as control drug including isovitexin, orientin, vitexin, caffeic acid, and p-coumaric acid. In addition, the findings demonstrated that the chemical bonds that facilitate the contact process are present in every substance that forms a binding interaction with the target protein. As a result, our findings provide preliminary evidence that the V. radiata plant has the potential to act as an anti-viral medicine that is effective against hepatitis C virus E2 envelope glycoprotein. © 2023 Malaysian Society for Biochemistry and Molecular Biology. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia; Biotechnology Study Program, Department of Applied Sciences, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia; Research Center for Plant Conservation Botanical Gardens and Forestry, National Research and National Agency (BRIN), West Java, Indonesia; Health Governance Initiative, United Nations Development Programme Indonesia, Eijkman-RSCM Building, Jakarta, Indonesia; Tropical Medicine International Program, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Pakuan, West Java, Indonesia
