Mega Nuraini, Subandi Subandi, Muntholib Muntholib, Suharti Suharti, Eli Hendrik Sanjaya
Obesity is caused by fat accumulation resulting from the low performance of pancreatic lipase enzyme, while gout is caused by the increase of uric acid in the blood due to the imbalanced production and excretion of uric acid. These diseases can be maintained by reducing foods containing high purines (gout), high carbohydrates and fats (obesity). Orlistat is a synthetic drug which is used to reduce excess fat in the body to inhibit pancreatic lipase enzyme, while allopurinol is synthetic drug used to reduce uric acid levels by inhibiting xanthine oxidase enzyme. Both synthetic drugs have several negative side effects on health, therefore, it is urgent to find out natural medicine which has minimum negative effects. There are several steps in this research design includes preparations of sugar apple and watermelon mesocarp; characterization using SEM-EDX; qualitative phytochemicals test; investigate the inhibitory relative of sugar apples to one tablet orlistat; and investigate the inhibitory relative of watermelon mesocarp to one tablet allopurinol. The results showed that the percentage yield of sugar apple was 8.18% and the percentage yield of watermelon mesocarp was 2.46%. Characterizations with SEM showed that average of particles diameter of sugar apple powder and watermelon mesocarp were 20.167 μm and 17.236 μm. The EDX analysis showed that sugar apple contains element K (0,60%) while watermelon mesocarp has several minerals: Mg (0.47%), Al (0.33%), P (0.60%), Cl (0.79%), K (3.02%), and Ca (0.39%). Both brewed sugar apple and watermelon mesocarp contain secondary metabolites flavonoid and polyphenol. The inhibition activity of brewed 1.5?g/150?mL sugar apple to pancreatic lipase enzyme was 18.05% while the inhibition activity of brewed 1.5?g/150?mL watermelon mesocarp to xanthine oxidase was 19.75%. Therefore, it can be concluded that extracts of sugar apple and watermelon mesocarp have potency as natural drugs with double benefit as anti-obesity and anti-gout. © 2023 Author(s).
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia
