Illa Aminatul Azizah, Ahmad Taufiq, Joko Utomo, Sunaryono, Arif Hidayat, Nandang Mufti, S. T. Ulfawanti Intan Subadra
In this research, silver/Ti-ferrite nanocomposite was successfully synthesized from Indonesian natural iron sand for drug delivery agent. The silver nanoparticle was synthesized using the reduction method, and the synthesis of Ti-ferrite used a coprecipitation method with a soft template. The sample was characterized by XRD, FTIR, and SEM to determine the structure, functional groups, and morphology, respectively. Meanwhile, drug delivery performance was characterized by UV-Vis. The XRD pattern presented the spinel cubic for Ti-ferrite nanoparticle with the highest diffraction peak at 2θ of 35.6o, and face-centered cubic for silver nanoparticle at 2θ of 38.18o. The FTIR spectrum confirmed the presence of Ti-Ferrite at wavenumbers of 418 cm-1 and 669 cm-1 for Fe-O and 518 cm-1 for Ti-O. The SEM image showed that the morphology of silver/Ti-Ferrite nanocomposite had a particle size distribution of 40.1 nm. Furthermore, UV-Vis data analysis showed the doxorubicin peaks found at wavelengths of 233, 255, 296, and 497 nm. Based on drug loading and drug release analysis, the silver/Ti-ferrite nanocomposite has the potential to be applied as a drug delivery agent with a high release of 83%. © 2024 Author(s).
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia
