Muhammad Hariz Asraf, Nik Ahmad Nizam Nik Malek, Muhammad Redza Mohd Radzi, Hendra Susanto
Conventionally synthesized silver nanoparticles (AgNP) imposed an alarming effect on the environment and caused toxicity to humans. However, the use of zeolite (zeoY) as a support system could increase its biocompatibility and reduce its toxicity. Hence, green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis technique. The phytochemical compounds in the optimized leaf extract concentration of 1% and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y pores. Morphological observation revealed the incorporation of AgNP in the zeolite Y (average size: 18.51 nm). The release of AgNP exhibited antibacterial activity on C. acnes at a concentration lower than 1 g L−1 which is also dependent on the electrolyte. AgNP-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model. © 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Johor, Skudai, 81310, Malaysia; Centre for Sustainable Nanomaterials (CSNano), Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, UTM, Johor, 81310, Malaysia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia
