Siti Imroatul Maslikah, Heri Prayitno, Muhaimin Rifa`i, Warsito Warsito, Muhammad Sasmito Djati
Background: Piper crocatum extract contains bioactive compounds, such as flavonoids and phenolics, that exhibit anti-inflammatory activity by inhibiting cyclooxygenase-2, suppressing nuclear factor kappa B, and modulating pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6. Liposomal encapsulation enhances these compounds’ stability, bioavailability, and targeted delivery, making it a promising strategy for anti-inflammatory drug development. Aim: This review evaluates the potential of P. crocatum liposomes as drug carriers for inflammatory disorders and identifies key research gaps. Methods: A systematic literature review was conducted using the Scopus database, following the PRISMA 2020 protocol and assisted by Parsif.ai for screening and data extraction. Results: Piper crocatum liposomes improved the physicochemical stability and therapeutic activity of encapsulated compounds, exhibiting enhanced antibacterial and anti-inflammatory effects. Their ability to modulate inflammation at the molecular level and deliver agents to specific sites demonstrates strong potential for therapeutic and preservative applications. Conclusion: Piper crocatum liposomal formulations offer a stable and effective delivery system for inflammation-related therapies, supporting further investigation into their clinical and pharmaceutical applications. © 2025, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia; Dewan Jamu Indonesia East Java Region, Malang, Indonesia; Brawijaya Library, Brawijaya University, Malang, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia; Innovation Center of Integrative Jamu and Ecopharmaca, Brawijaya University, Malang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia
