Reny Citra Sanjaya, Joko Utomo, S. T. Ulfawanti Intan Subadra, Muhammad Safwan Abd Aziz, Nurul Hidayat, Ahmad Taufiq
Fe3O4/Hydroxyapatite (HA)-(3-Aminopropyl)triethoxysilane (APTES) nanocomposite as a drug delivery agent was successfully synthesized. The nanocomposite was characterized using X-ray diffractometry (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), and ultraviolet-visible (UV-Vis) spectroscopy to investigate the structural, morphology, magnetic properties, and DOX drug loading and release efficiency. The XRD pattern of Fe3O4 /HA-APTES nanocomposite showed the formation of two phases with cubic spinel structure for Fe3O4 and hexagonal structure for HA. The SEM image showed that the nanocomposite morphology tended to be granular (though not perfectly granular) with a particle size distribution of 65.9 nm. The functional groups detected from the FTIR results were Fe-O at 422–602 cm-1, indicating Fe3O4. Furthermore, vibrations of the phosphate group (PO43-) and Si-O-C appeared at 1037 cm-1 and 1048 cm-1, which are characteristic of the phosphate stretch in the HA and APTES. The Fe3O4/HA-APTES nanocomposite exhibited superparamagnetic properties with a saturation magnetization value of 19.37 emu/g. As a drug delivery agent, the Fe3O4/HA-APTES nanocomposite has a DOX loading efficiency of 5.79 mg/g up to 96.51% for eight hours and a release of 16.36% over 300 min. © 2025 Trans Tech Publications Ltd. All Rights Reserved
Department of Physics, Faculty of Mathematics and Natural Sciences, State University of Malang, Indonesia; Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, Johor, Skudai, 81310, Malaysia; Laser Center, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Malaysia
