Hadiono, Denaz Karuma Hijriansyah, Rickadesti Ramadhana, Agus Pribadi, Nuril Huda, Andryas Yuniarto, Imam Hariadi, Yona Bayu Prasetyo
This study aims to determine the effect of High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) exercises seen from the biomolecular parameters of Interleukin-6 (IL-6). Male Rattus Norvegicus mice used aged 2-3 months with obesity status were trained 4 times a week for 6 weeks. HIIT uses an intensity of 90-100% of the total maximum speed/baseline with an interval of 1: 1 (2 minutes active: 2 minutes rest) for 15 minutes/exercise. MIT uses an intensity of 50-60% of the total maximum speed/baseline for 30 minutes/exercise. IL-6 levels were tested using Elisa. There was a significant difference (P = 0.000) in the three groups at the end of the study. The results of body weight between the HIIT and control groups were (P = 0.000), while the MIT and control groups were (0.002). The results of IL-6 levels in the HIIT group and the control group were significantly different with a P value of 0.000, while in the HIIT group and the MIT group the significance value was P = 0.002. The conclusion of this study shows that IL-6 levels in the HIIT group were lower than those in the MIT group and the control group. Although HIIT is effective in losing weight, it still needs to be monitored and strictly controlled, considering that HIIT is a high-intensity activity to avoid injury. © 2025, Campus EDUCA SPORTIS S.L.. All rights reserved.
Universitas PGRI Yogyakarta, Indonesia; Universitas Negeri Malang, Indonesia; Universitas PGRI Madiun, Indonesia
